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Schafer, F

Additionally, TMAO prevents cardiac mitochondria from oxidizing fatty acids and pyruvate, which may have an impact on energy metabolism [44]

Its incidence is increasing [25], probably because of the use of VPA in psychiatric disorders

Other chronic disorders, including Alzheimer's disease, diabetes, and heart failure, when combined with diseases that induce improved catabolism, could result in SCD (Kepka et al., 2020)

Finally, the effectiveness and feasibility of targeting APOA4 and PCSK9 in clinical treatment remain to be demonstrated