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These targets represent the rationale for interventions aiming to modulate aberrant bone remodeling, suppress catabolic cytokine signaling, restore anabolic growth-factor balance or selectively eliminate senescent cells, thereby shifting treatment goals toward true disease modification

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People at a higher risk of B12 deficiencies include older adults, people who suffer from gastrointestinal disorders or have had gastrointestinal surgeries, and anyone who adheres to a vegan or vegetarian diet