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189,190 Finally, the diol 10( E ),12( Z ),14( E )-9( S ),16( S )-DiHOTrE has been identified after further oxidation of 9( S )-HpOTrE (an ALA-metabolite of plant 5-LOX) by human 15-LOX-2

Ann lInstitut Pasteur (1965) 109(5):798810

10.1016/j.ajhg.2024.04.015 55 FernandesM.LopesI.MagalhesL.SrriaM

Kidney diseases, specifically acute kidney injury (AKI) and chronic kidney disease (CKD), represent major global health burdens.3,4 The pathophysiology of these renal diseases involves interconnected mechanisms, notably inflammation, fibrosis, and oxidative stress, with the excessive generation of reactive oxygen species playing a critical role in disease initiation and progression.5,6 Consequently, therapeutic strategies that modulate oxidative stress and associated redox-sensitive signaling pathways are increasingly relevant to nephrological research and clinical practice

Wahab S et al

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