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Because of its ability to increase intestinal permeability, functional screening of Zot protein was conducted, leading to the discovery of a human intestinal Zot analogue, zonulin, which, like Zot, has been shown to reduce TEER of intestinal tissue (7)

Clinical studies of GHK-Cu combined with 15% L-ascorbic acid demonstrate additive improvements in photoaging parameters, with combination formulations producing 35-45% greater wrinkle reductions than either agent alone

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