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, poly ADP ribose polymerase [PARP]), together leading to an increase in the NADH/NAD + ratio and promoting ROS production by mitochondrial respiratory complex I due to NADH overload, eventually resulting in reductive stress (38, 105, 107)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 203.Cacciatore I., Cornacchia C., Pinnen F., Mollica A., Di Stefano A

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