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In active acromegaly, many observations show that due to the high GH levels, glucose levels tend to be elevated, which is accompanied by the well-known high insulin levels in untreated acromegaly patients [33,34]

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In the Japanese cross-sectional study on adolescents (aged 1215), higher riboflavin in blood were also associated with less depressive symptoms in girls ( n = 3450), but not boys ( n = 3067) 59

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