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Moreover, inhibiting fumarate hydratase, a critical enzyme of the citric acid cycle (CAC), reduces the long-term repopulating potential of HSCs (15)

PMID: 35174734 Karamian, B.A., DiMaria, S.L., Sawires, A.N., Canseco, J.A., Basques, B.A., Toci, G.R., Radcliff, K.E., Rihn, J.A., Kaye, I.D., Hilibrand, A.S., Lee, J.K., Kepler, C.K., Vaccaro, A.R., Schroeder, G.D.: Clinical Outcomes of Robotic Versus Freehand Pedicle Screw Placement After One-to Three-Level Lumbar Fusion

10.1001/archinte.127.5.934 341 WheltonA

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This is in marked contrast to earlier studies that focused on the role of the intracellular C-terminus in desensitization