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Isolated mitochondria from whole mouse brain show a decrease in complex I activity, though there appeared to be an agent-specific difference in the magnitude of this reduction, with ISO inducing the largest response (96, 101)

Desoye, G

L., Torheim, L

Makovec T
They hypothesized that during the process of brain masculinization (exposure to high levels of testosterone) the brain is more susceptible to immune activation and/or neurotoxins