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The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure

doi: 10.1097/00000441-200209000-00003

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Zukin R.S

Mechanistically, these changes appear to coincide with elevated NAD+ and activation of metabolic gene programs consistent with increased energy expenditure

Possible interaction between warfarin and fluconazole

In the case of skin pigmentation: Iron-deficient skin struggles with optimal oxygenation and collagen synthesis, weakening its defense against UV damage and stress-induced oxidants