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2 Mitochondrial dysfunction in ASD From a clinical point of view, mitochondrial dysfunction in ASD may be the cause of seizures, motor delay, fatigue and neurodevelopmental regression ( Mitochondrial dysfunction itself can be categorized into two types: the first type represents a mutation of a gene which is associated with the ATP-generating pathway, while the second one is related to various abnormalities such as genetic, biochemic or metabolic, that may weaken the ability of the mitochondria to produce ATP ( A central mechanism often implicated is the dysfunction of Electron Transport Chain (ETC), which plays a crucial role in ATP production

Two tannin hydrolysates, chebulagic acid and chebulinic acid , were identified as potent ferroptosis inhibitors

B12 deficiency can cause fatigue and slow metabolism

Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial Phytomedicine (2015), DOI: 10.1016/j.phymed.2015.01.010 7

We next examined the organization of PGL-1::RFP and GFP::ZNFX-1 granules