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Helpful details to share include: Exactly how the sensation feels (tightness, choking, lump, fullness) When it occurs (always, after eating, at night, during stress) Any associated symptoms (heartburn, cough, voice change, weight loss, fever) Recent infections, new medications, and smoking or alcohol habits These details let clinicians prioritize tests and avoid unnecessary procedures

Multi-omics technologies provide a potential means to integrate information across cells, molecules, and spatial contexts into models that connect etiology, mechanisms, and therapeutic responsiveness

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Clifton GT, Peoples GE, Mittendorf EA

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