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Both approaches are valid

Another strength of this study is that it was based on a narrow age range, thus minimizing age-dependent variations

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Shalita et al 41 found that patients with inflammatory acne showed significant improvement in acne severity and appearance when a combination of nicotinamide, azelaic acid, pyridoxine, copper, and folic acid was added to existing acne regimens at both four and eight week follow up
Molecular profiling of inflammatory processes in a mouse model of IC/BPS: from the complete transcriptome to major sex-related histological features of the urinary bladder