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PD146176, a 15 LOX inhibitor prevents cell death in GPX/ mouse embryonic fibroblast and in human fibrosarcoma cells exposed to erastin.31,85 Iron chelation prevents ferroptosis and diverse iron chelating strategies were successfully used in experimental heme-associated AKI in the early nineties (e.g

In addition, compared to placebo, patients receiving selegiline developed freezing of gait and on-off motor fluctuations less frequently

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doi: 10.1016/0024-3205(92)90302-6 69 OwnbyCLPowellJRJiangMFletcherJE

By loading DOX in a delivery system that selectively binds with cellular receptors overexpressed by the cancerous cells, 11 the delivery of DOX to the tumor region can be enhanced, the accumulation of DOX in the heart can be reduced, and the specificity of DOX can be improved