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Description
Metabolically activated proteostasis regulators protect against glutamate toxicity by activating NRF2

Here, they undergo incomplete, alternative oxidation pathways that generate massive amounts of free radicals and reactive oxygen species (ROS), further damaging the delicate mitochondrial membranes and the very enzymes required for energy production

Abstract The lack of biomarkers greatly limits the diagnosis and treatment of major depressive disorder (MDD)
2, 2019, pp

Putamen mitochondrial energy metabolism is highly correlated to emotional and intellectual impairment in schizophrenics

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