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Luteolin can also increase the expression of antioxidant enzymes such as heme oxygenase-1 (HO-1) via the nuclear factor erythroid 2related factor 2/ antioxidant responsive element (Nrf-2/ARE) complex activation, as it was observed in in vitro models of PD [44, 57] and H 2 O 2 -induced toxicity in in vitro models [5860]

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Therapeutic peptides generally work by binding to cellular surfaces and triggering effects within the cells

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In this model, a significant main effect for treatment group indicates an overall treatment effect over the entire study period