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If methylation is not working properly due to various B vitamin deficiencies, disease states, or genetic mishap, higher levels of homocysteine may result

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Underlying Conditions and Treatment Side Effects Dry or cracked lips may also result from medical conditions or side effects from medications, supplements, or cancer treatments

The oxidized form (GSSG) has already "spent" its electron and is inactive until the body recycles it

I did not hear of anyone else with this experience for dose 1 so I feel much better that I am not the only one