aspirin glutathione adduct PDF] Does aspirin-induced oxidative stress cause asthma exacerbation? Targeting MRP4 in drug resistance

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[DOI] [PubMed] [Google Scholar] 5.Kamat CD, Gadal S, Mhatre M, Williamson KS, Pye QN, Hensley K

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Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans