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That rationale must be backed by non-clinical data confirming the compound behaves as expected and by a thorough safety and toxicology program that identifies potential risks and establishes a safe starting dose for the first human administration and the maximum human exposure that should not be surpassed

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PMID: 36052678

However, wild-type p53 could delay induction of ferroptosis by regulating its transcriptional target CDKN1A (encoding p21)

The gut microbiota has also been demonstrated to influence sex hormone levels by modulating sex hormone-related enzymes and enterohepatic circulation, impacting the hypothalamic-pituitary-testicular axis and promoting sexual arousal and behaviour [216]

In the next blog, I will be speaking about Ehlers-Danlos syndromes co-morbidities, what conditions EDS can cause, and their treatments