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All findings described here are from controlled preclinical research settings

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These rapid changes in organization cause cells to experience stretch, pressure, and shear stress, which cause mechanoactivation of various proteins, such as cadherins, caveolins, Rho, and cdc42, and aid in development in normal physiological conditions ( vegfr-2 in a genetically-modified mouse model is embryonically lethal by stage E10.5 and showed no vasculature, suggesting that VEGFR-2 is required for vasculogenesis in development ( Angiogenesis in Tissue Engineering While there has been a significant rise in interest for tissue engineered scaffolds for replacement of disease tissues or organs in recent years, generation of large-scale systems has been limited by size restrictions due to limited nutrient diffusion

Although differences in the rates at which men and women develop Alzheimer's or other dementias do not appear to be large or consistent, the reasons men and women develop dementia may vary

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Growth factors have also been proven effective in vivo in animal models with experimentally induced IVD degeneration (Additional file 1)