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For increased sensitivity, data was also acquired using positive mode with single ion monitoring for TML and d9-TML, m/z 189 4 and 198.22 4, respectively, at a resolution of 7,500

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73,74 DSM-5-TR guidelines recognize the challenge of differentiating hypersomnolence disorder from other psychiatric disorders that may involve hypersomnolence or fatigue and the possible bidirectional relationship between hypersomnolence and depressive symptoms