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Src family molecules such as Shc and Lyn, interact with the cytoplasmic domain of the GHR and activate phospholipase C (PLC) which then proceeds to hydrolyse phospholipids to form inositol-1,4,5 triphosphate (IP3) and diacylglycerol (DAG) (47)

In other words, when DP cells are cultured longer and passaged more, they are less effective in generating functional hair follicles post-transplantation 15

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A GH receptor antisense oligonucleotide inhibits hepatic GH receptor expression, IGF-I production and body weight gain in normal mice

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