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For instance, an elevated ROS production by the respiratory chain is observed in obesity as a response to metabolic overload caused by excess macronutrients and increased substrate availability ( Several enzymatic and non-enzymatic defence mechanisms that guard cells against free radical damage have been identified in different cellular localizations, including mitochondria, plasma membrane, endoplasmic reticulum, peroxisomes, and cytosol

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Each mouse underwent four trials, with the platform placed in two different locations

As Dvl interacts with Axin (Wallingford and Habas, 2005), and is required for Axin recruitment to the plasma membrane during Wg signaling (Cliffe et al., 2003) or in Fz overexpression (Zeng et al., 2008), one model stipulates that Fz-Dvl recruitment of the Axin-GSK3 complex initiates LRP6 phosphorylation by GSK3 (Zeng et al., 2008) (Figure 5)

Sci Transl Med 4:141ra90 [DOI] [PMC free article] [PubMed] [Google Scholar] 79.Kouroupi G, Taoufik E, Vlachos IS, Tsioras K, Antoniou N, Papastefanaki F, Chroni-Tzartou D, Wrasidlo W, Bohl D, Stellas D et al (2017) Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinsons disease

PMC 5390862
