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Once a dog has begun taking a vitamin B12 supplement, small improvements may be seen in just a few days, but it can take several weeks before the dog fully responds to treatment.

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Conflict of interest The authors declare that they have no competing interests

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The researchers commented that these might include important systems, namely, dopamine-, NO-, prostaglandin-, somatosensory neuron-system, and more

Studies suggest there is no difference in efficacy between the different delivery methods