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Relative bioavailability of generic and branded acetylcysteine effervescent tablets: A single-dose, open-label, randomized-sequence, two-period crossover study in fasting healthy chinese male volunteers

Since ROS-dependent DNA damage is markedly increased in myeloid cells after Bcr-Abl transformation 18 , we hypothesize that blocking dTTP and dCTP supply might exacerbate replication stress and DNA damage in Bcr-Abl-transformed cells, thereby jeopardizing cell survival

doi: 10.1016/j.jinorgbio.2012.06.004

Sakura T, Hayakawa F, Sugiura I, Murayama T, Imai K, Usui N, Fujisawa S, Yamauchi T, Yujiri T, Kakihana K, Ito Y, Kanamori H, Ueda Y, Miyata Y, Kurokawa M, Asou N, Ohnishi K, Ohtake S, Kobayashi Y, Matsuo K, Kiyoi H, Miyazaki Y, Naoe T

Therefore, Gln deprivation-induced iron death in tumor cells may represent a novel therapeutic strategy for liver tumors (47)

[DOI] [PubMed] [Google Scholar] 48.Zheng H., Wei J., Wang L., Wang Q., Zhao J., Chen S., Wei F., Kennedy D.A