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FSH levels followed a similar pattern, although they were suppressed to a lesser extent and the decline was slower

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Methods Expression constructs Expression constructs of indicated proteins were cloned into indicated vectors using PCR or the gateway system

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Glossary AGEs advanced glycosylation end products AKT protein kinase B BBL broadband light BCL2 B-cell lymphoma 2 BAX BCL2-associated X protein CCL2 C-C motif chemokine ligand 2 CDKN2A cyclin-dependent kinase inhibitor 2A COL1A1 collagen type I alpha 1 chain COL3A1 collagen type III alpha 1 chain CTCF CCCTC binding factor CXCL8 C-X-C motif chemokine ligand 8 DHM dihydromyricetin DHMT1 DNA methyltransferase 1 FOXO3 forkhead box O3 GC-MS gas chromatography-mass spectrometry GC-TOF/MS gas chromatography time-of-flight mass spectrometry IL-1 interleukin 1 beta IL-6 interleukin 6 LC-MS liquid chromatography-mass spectrometry MMP1 matrix metalloproteinase 1 MMP3 matrix metalloproteinase 3 MMP9 matrix metalloproteinase 9 miRNA microRNA NMR nuclear magnetic resonance Nrf2 nuclear factor erythroid 2-related factor 2 RNA-seq RNA sequencing ROS reactive oxygen species SIRT1 sirtuin 1 SGLT2 sodium-glucose cotransporter 2 SOD2 superoxide dismutase 2 TFs transcription factors TNF- tumor necrosis factor alpha UVA ultraviolet A radiation References 1 AhlersJ