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doi: 10.1080/07315724.2004.10719347

In the normoxic state, HIF-1 is inactivated by proline hydroxylases (PHDs) and VHL within the cytosol

Serving aging population

Specifically, preliminary data suggest that oral administration of excess Mn (15 mg/kg/day, administered orally by gavage for 30 days) affects fecal metabolomics, including decreased levels of fecal butyrate, -tocopherol, and bile acids and increased levels of palmitic acid and bile acids in rat feces, which may partially mediate the effects of Mn in the body (125)

Brain 131 , 14641477 (2008)

Pathogen-induced, NADPH oxidasederived reactive oxygen intermediates suppress spread of cell death in Arabidopsis thaliana