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Studies have shown that the hexosamine pathway plays a role in mediating ROS-induced toxicity under hyperglycemic conditions (34, 35)

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For higher doses or when absorption is poor, they can be given through a vein

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As many as 20% of older people have problems getting B12 from the diet." And research shows that risk of developing gastric atrophy, and ensuing B12 deficiency, doubles between the ages of 50 and 70