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We found an adverse effect of high glucose on PDLSC osteogenic differentiation in this study, as evidenced by a significant decrease in cellular ALP activity, formation of mineralized nodules, and expression levels of osteogenesis-related proteins and genes ( Figure 1 )

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[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Reichel C.M., Moussawi K., Do P.H., Kalivas P.W., See R.E

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Additionally, it has been shown that sleep deprivation accelerates aging through disrupting the redox homeostasis dominated by non-radicals

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