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Conversely, late processes, such as T cell clonal expansion and cytokine release are highly sensitive to the lack of glutamine, predicting that glutamine is partially important for pro-inflammatory effector functions of T cells

Several factors are recognized to contribute to its development including an overgeneration of reactive oxygen species (ROS)

doi: 10.1016/j.bbamcr.2004.10.013, 72

Lu X, Li Y, Li X, Aisa HA (2017) Luteolin induces apoptosis in vitro through suppressing the MAPK and PI3K signaling pathways in gastric cancer

A recent study on the importance of metabolites produced by the gut microbiome in regulating neurological disorders defined the gut-brain axis as follows: The microbiota gut-brain axis (MGBA) is a term used to describe the link between the gut and the brain involving the interplay of several systems, mainly the autonomic, central, and enteric nervous systems and the hypothalamic-pituitary axis (Swer et al., 2023)

See, for example, the Nobel Prize Nomination Database: Mothers and daughters of invention: notes for a revised history of technology
