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Gene- and proteostasis-based strategies for monogenic disorders For diseases driven by single-transporter defects, gene-based therapies and pharmacological chaperones that restore proper trafficking, stability or function of mutant zinc transporters represent plausible longer-term strategies

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As the number of worms measured is known to influence the likelihood of accurately observing differences in lifespan (Petrascheck and Miller, 2017), the starting populations for all treatments within experiments were in excess of 70 individuals

It functions as an acceptor of carbamyl phosphate