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These and other agents work together to increase oxidative stress in our bodies, creating highly reactive molecules called free radicals that can cause severe damage to our cells

In their study, high-dose anti-VEGFR2 treatment aggravated intratumoral hypoxia and restrained the infiltration of CD8 + T cells into the TME, thereby suppressing anti-cancer immunity

doi: 10.1016/j.sjbs.2020.05.018 [DOI] [PMC free article] [PubMed] [Google Scholar] 115

Ashok AH, Mizuno Y, Volkow ND, Howes OD

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Mutations in persulfite dioxygenase, oxidizing GSSH to sulfite and GSH, are bases for autosomal-recessive inherited ethylmalonic encephalopathy [112]