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Patients should contact their insurance providers to inquire about their specific plan's coverage for clinical trials

Limitations and future directions Given that tesofensine is a triple reuptake inhibitor that regulates the level of DA, 5-HT, and NE across the entire brain, its effects are expected to be distributed and brain-wide, certainly not restricted to LH or GABAergic neurons

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Standard: Move to 5 mg once daily from day 3 onward

Cellular senescence: "Zombie cells" that secrete inflammatory factors, promoting further aging

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