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In total, 12 SPMS patient donors and 10 non-demented control donors were selected

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We then made both single and double mutations on both of the ERE binding sites (located at 1005 and 944) in the pOXTR full length construct, and the reporter assay showed that ERE single mutants (M-1005/ERE, M-944/ERE) significantly decreased OXTR reporter activity in the LG treatment group compared to the wild type full length (pOXTR-2000/LG), while ERE double mutants (M-1005/-944/ERE) further decreased reporter activity, mimicking the reporter activity of the full length reporter construct (pOXTR-2000) in the HG treatment (see Figure 2D)

[31] Are pediatric doses the same as adult doses

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