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acknowledges support from the NIH (R37CA240625, R01CA259111, R01CA298386, P30CA010815 and P30CA047904), the Sandy Rollman Ovarian Cancer Foundation, the American Cancer Society (RSG-19-113-01-CCG), the Congressionally Directed Medical Research Program (HT9425-23-1-0436), the UPMC Hillman Cancer Center and the Wistar Institute

Local Action and Transdermal Absorption Transdermal absorption mechanism: L-carnitine enters the subcutaneous fat layer through pathways such as diffusion through the stratum corneum, penetration through hair follicles and sweat glands

ALCAR inhibits MMP9 which could be involved in invasive features of PCa and BPH cell lines

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Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different