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3HSD2 is also responsible for the conversion of E2 into E1

Despite these findings, the role of the GCH1-BH4 pathway in the ferroptosis of PDAC remains to be fully elucidated, necessitating further research

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Proc Natl Acad Sci USA 114:89148916 Lander HM, Ogiste JS, Pearce SFA et al (1995) Nitric oxide-stimulated guanine nucleotide exchange on p21ras

Polymorphisms in the 5-aminoimidazole-4-carboxamide-ribonucleotide formyltransferase ( T102C ) and gamma-glutamyl hydrolase ( G91T ) genes have also been linked to both adverse reactions and therapeutic outcomes [363]