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Concurrently, GHK-Cu influences MAPK pathways including ERK1/2, p38, and JNK, with effects varying based on cellular context and stimulation conditions

Several critical questions remain unresolved: (1) most existing studies are confined to animal and cellular models, with a notable lack of large-scale population-based investigations and clinical validation, thereby impeding translational application

C., Jackson, C

demonstrated that heme oxygenase-1 (HO-1) in hUC-MSCs regulates autophagy and up-regulates CD8 + T cell cycling through activation of the c-Jun N-terminal kinase/ B-cell lymphoma 2 (JNK/Bcl-2) signaling pathway, which contributes to restoring ovarian function in POF mice [112]

(1986) reported that taurine (462 mg/kg/day) in guinea pigs for 2 weeks results in fatty infiltration of the liver [30]

Roxas and Viswanathan 2018)