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Our data also reveal the interdependence of lipid peroxidation and iron overload in ferroptosis signaling, as blockade of either pathway prevented oxidative stress-induced ferroptosis in cardiomyocytes

While some heavy metals are essential in trace amounts for biological processes (e.g., zinc, iron, and copper), others are toxic even at low concentrations (e.g., Cd, Hg, and Pb)

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Such dysregulation provides a mechanistic link between hormonal imbalance and chronic local immune activation, contributing to the sustained inflammatory milieu underlying pelvic pain in both conditions