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These observations suggest that there is a critical glutathione status below which the accumulation of pathogen-defense related molecules and consequently disease resistance, is impaired

Although there was no expectation that acute loss of function would match that from chronic reduction, we still observed several splicing alterations in the mutant fibroblasts that showed the same trends as the changes produced by FUS/TLS or SMN knockdown

Studies suggest that curcumin may alleviate epileptic seizures by modulating oxidative stress, neuroinflammation, and neurotransmission while also inhibiting apoptotic cell death and necrotic and autophagic pathways in hippocampal neurons[374-376]

Neuronal versus glial cell swelling in the ischaemic retina