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Therefore, new antidepressants with different mechanisms are needed to enable clinicians to diversify the treatment options for MDD

Regarding its use in vulnerable populations, such as pregnant or lactating individuals and young children, available data are limited or nonexistent

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Providers avoid this treatment for hemorrhagic strokes, where bleeding occurs in the brain

A central mechanism driving such pathological scarring is the persistent activation of the transforming growth factor-beta (TGF- )/Smad signaling pathway, which continuously stimulates fibroblasts and myofibroblasts, resulting in excessive collagen deposition and fibrotic remodeling (31, 32)

Th17 balance seems to be elevated in tumor immunity in patients undergoing ICI treatment [42] and in BALF from active sarcoidosis [43,44]