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Another recent metabolomic study evaluated 131 blood metabolites as frailty markers in elderly hospital patients (Reference Kameda, Teruya and Yanagida18)

Although the pathophysiologic functions of PGD 2 and PGE 2 in FCMD remain unclear, certain predictions can be made based on previous studies on other muscular dystrophies including DMD 11,24

Both reactions involve the activated conjugated agent coenzyme A (CoA) as a cofactor and require the formation of a thioester with the carboxylic group, either of acetate, or of the xenobiotic

Moreover, a recent multi-omics investigation demonstrated that EGCG enhances the epigenetic effect of decitabine in the treatment of acute myeloid leukemia by promoting the reactivation of TSGs (Addissouky, 2025)