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For instance, Allan et al

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And enhances mitochondrial function, thermogenesis, and fat oxidation

Methylcobalamin is a naturally occurring form of B12, and it is the most bioavailable

However, unlike the consistent long-term effect induced by L-NAME retrobulbar application, there was only limited detrimental retinal effect at 40 min after intravitreous L-NAME application in cats lasting only for 180 min [179]

Future studies should explore means of restoring BBB integrity, which could extend scientific knowledge and contribute to novel therapeutic targets