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Also in neurons, ASIC1a mediates pH-dependent calcium transport into the mitochondria, increasing respiration and metabolic rate [101]
While both doses significantly improved testosterone levels, neither fully restored it to normal values, with the 7 mg/kg and 14 mg/kg doses remaining 38.1% and 20.8% below normal levels, respectively
Researchers are still able to tease out valuable information on mechanistic and novel treatments
The resulting perturbation to [Fe-S] clusters, TCA and OXPHOS may cause reductive stress, adding to cytotoxic effects at this timepoint
Tosti A
10.1186/s12967-016-1058-7 151
