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These findings help to explain why leptin replacement does not completely reverse the neuroendocrine adaptations induced by weight loss 1, 3, 5 , since both GH and leptin play a role informing the brain about energy deficiency

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One in vivo comparison of GHK versus GHK-Cu in rat experimental wounds found that GHK alone had no effect, and only the copper-bound GHK-Cu form produced a statistically significant increase in collagen accumulation evidence that the copper ion itself, not the peptide backbone alone, may be responsible for much of the collagen-stimulating activity

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