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The mechanism by which bacteria traverse the mucosal barrier remains unclear, with the most convincing studies suggesting that a specific transcytotic process involving specialized cells overlying the domes of intestinal lymphoid aggregates (Peyers patches) termed M-cells, which are characterized by a sparse glycocalyx, short and irregular microvilli and a microfold appearance [16, 17]

One of MOTS-C's downstream effects is increasing intracellular NAD+ utilization the mitochondria are running harder, so they're consuming more of the NAD+ pool

The vast majority of studies are in rats and mice

P., Ahmed, S