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doi: 10.1001/jama.1961.73040330027011c

doi:10.2215/cjn.05560515 Rull G, Mohd-Zain ZN, Shiel J, et al

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Caffeine (from natural sources): May support metabolic rate and energy expenditure (1)

But when the balance of neurotransmitters that excite to neurotransmitters that relax is thrown off, then mood disorders can result

(2018), ketamine reduced craving and self-administration of cocaine in non-treatment-seeking cocaine users, demonstrating how its effects on the brains reward systems contribute to psychological dependency while also increasing physical risks