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347,348 High glucose levels inhibit the PI3K/Akt pathway in Schwann cells, leading to overexpression of DNA methyltransferases (DNMT1 and DNMT3a) and upregulation of thioredoxin-interacting protein (TXNIP)
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Several genes encoding proteins involved in nuclear phosphoinositide homeostasis have been shown to be mutated in various cancers
10.1136/postgradmedj-2018-136029 13 MarquesP
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