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The TME consists of a heterogeneous array of cell populations including endothelial cells, fibroblasts, immune cells, and adipocytes, which are embedded within extracellular matrix and various cytokines, growth factors, chemokines, and extracellular vesicles, frequently characterized by suboptimal nutrient and oxygen delivery, as well as inefficient waste removal [11]

These enzymes maintain redox homeostasis and prevent cellular dysfunction 45

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Imai H, Hirao F, Sakamoto T, Sekine K, Mizukura Y, Saito M, Kitamoto T, Hayasaka M, Hanaoka K, Nakagawa Y: Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene