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Xue Xiaochang, Wu Yongjie, Gao Mingtang, Li Wenguang, Zhao Ning, Wang Zenglu, Yan Zhen, Zhang Yingqi

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Patients with severe MTHFR deficiency (0-20% residual enzyme activity) in infancy or adolescence present with developmental delay, severe mental retardation, motor and gait dysfunction, seizures, psychiatric disturbances, and other neurological abnormalities

10.1182/blood.v92.4.1191.416k15_1191_1198 31 LanganR

This leads to the release and cytoplasmic translocation of p53, which can subsequently activate transcription-independent pro-apoptotic signaling (Clara et al., 2024

Control of penile erection by the melanocortinergic system experimental evidences and therapeutic perspectives
