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Calculation and analysis of all experimental results using GraphPad Prism 8.0

When its levels increase, it means the liver is damaged or not functioning properly

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Various derived metabolites such as SCFAs, SBAs, 5-HT, Hi, and vitamins are more often indicated as signaling molecules and substrates of metabolic reactions, which affect the distal bone tissues through pathway conduction and cascade, and participate in the formation, metabolism, and maintenance of the skeleton (41)

Moreover, prolonged elevation of TSH induces neovascularisation and increases the stromal vascularity as TSH acts as a growth factor for the thyroid tissue [20]

Elevated levels of homocysteine in the blood have been shown to correlate with cardiovascular dysfunction