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PAI-2 is inefficiently secreted, and the majority of the protein is retained intracellularly 49

Moreover, understanding the specific molecular mechanisms of antioxidants which interact with inflammatory mediators and immune cells can offer a more integrited insight of the pathways of antioxidant therapys efficacy

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Finally, the above approach to evaluate organoid-derived FVII function suggests that although these experiments are not specific for FVII activity per se, supernatants (supplemented with vitamin K) show hemostatic potential due to the secretion of serine proteases (probably gamma-carboxylated) into the conditioned medium that mimic the FVII effect